Archive for Perimenopause

I’m often invited to speak on issues of hormonal health to groups of women in their forties. Looking out over the audience, I see an amazing diversity among the women, some are still girlish, some are distinctly mature; some are fashionably slender, some are rounding out; some look energetic and alert, some a little tired. But what I can’t tell by looking is who is a grandmother, who a first-time mother of a preschooler, who a single woman over the span of adult life, who a divorced or widowed woman newly entering the category of “single woman.” Who of these women has chosen to pass up childbearing and remain “child free”? Who has been struggling for decades with infertility and is now considering adoption, and who is taking advantage of the innovative options for conception yielded by a virtually exploding technology? Who is in a stable, long-term relationship, and who is, for want of a better word, dating?

Such an audience, in all its diversity, is a perfect symbol for the subject: the forties, the transitional decade in a woman’s life. It’s the diversity itself that makes my audience a perfect symbol, because Although the decade is marked by changes as distinct as those between ages 10 and 20 each woman goes through them at her own pace and with her own physiological and hormonal “style.” The changes are the same, but the ways of undergoing them, and to some extent the time it takes to do so, are related to the individual.

The random person on the street, be it a woman or a man, wouldn’t necessarily agree that individual styles evolve within this decade of change. That’s because, in our youth-oriented culture, the forties have a bad reputation: too often they’re viewed as the last, desperate period of a woman’s real life before the end, menopause, that is, after which old age sets in with a vengeance. This stereotype is pervasive; I often hear it expressed by clients when they first come to my women’s health clinic, Full Circle. All too often they feel they’re headed toward a fall, speeding toward the cliff that will mark the end of their lives as attractive, productive, sexual women, so much so that they interpret the various changes they experience in body and psyche only as dreaded signals that they are fast approaching “the change.” The true nature of the forties decade, its physical, intellectual, and emotional qualities, are an indistinct blur, like the terrain outside the window of a supersonic train. My goal at my clinic is to shatter the “end of life” stereotype, to explain the particular processes and changes that characterize the forties, and to slow down the train.

The “last chance” stereotype persists for a good reason: we have too little information to the contrary. Even many of the most supportive books on menopause focus on it as if it suddenly happened sometime at the end of the forties or the beginning of the fifties, as if it were an event unrelated to anything that came before. In fact, although menopause is indeed a milestone on a woman’s developmental path, it is also a link in a long chain of events, physiological and psychological, that precedes it. To a greater or lesser degree, we experience these events as changes, and sometimes as distressing symptoms, in our bodies, our emotions, our sexuality, and in other areas of our lives. To a greater or lesser degree, the medical world has tended to brush aside these changes as “just signs of aging,” developments not worth treating and to which we women might as well just become accustomed. For this reason, most women get neither the information they need to understand what’s happening to them nor the advice or treatment, often pretty minimal, that could ease any discomfort they might experience.

There’s one more reason that the forties decade has remained in the shadows for us, and I say “us” accurately, for I am 47 as I write this. We women in our forties now are baby boomers, and during our teenage years our mothers were 1950s “ladies,” strapped by the conventions and conformities of that particularly stringent decade. In an effort to prevent all the “terrible symptoms” associated with menopause from developing, many of our mothers underwent hysterectomies before they plummeted off that cliff. Others followed the rules by simply not speaking of the “change of life,” and their silence added an aura of ominous gloom to the subject. So most of us have no role models for adapting to the changes in the transition decade with interest, initiative, and a commitment to self-care.

It is my aim, both in my clinic to change all that by filling in the information gap. Handily enough, although medical science has generally ignored the forties as vague and uninteresting, it has given a name to this portion of the developmental arc. That name is perimenopause, and the goal of my work as a medical caregiver and educator is to make that term as familiar to the general public as menopause is today.

The prefix peri literally means “that which surrounds,” but the word perimenopause is used to refer to the events leading up to menopause. For some women, perimenopause lasts less than a decade; for others, it is somewhat longer. Individuals experience perimenopause differently, just as they do the transition into fertility during puberty. Still for most women, the period of perimenopause roughly corresponds to the years from 40 to 50, and for those who fall outside that decade, the changes are the same.

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When we travel by car or train on a literal journey, we sometimes need to stop and look at a map or ask for directions, depending on our style. You’ll get your bearings on your path through the hormonal landscape, where you’re in charge of navigating, where the map is unique to you, and where you decide which steps are best for you.

A basic understanding of how our hormones work is necessary to be able to interpret the changes we experience, explain them to our families, and evaluate our choices thoroughly and carefully. After all, the more you know about how your body matures, the more secure you’ll feel that nothing is going “wrong” with you, and the better equipped you’ll be to form an effective support system with your family, friends, and health care providers.

Of course, to explain all of the complex interactions our hormones have with each other and with other chemicals produced in our bodies and brains, I would have to write a weighty medical textbook. Instead, my purpose here is to give you a basic overview of the subtle and elegant ways our bodies produce and use hormones. “Just the basics” will help you understand how our bodies work hormonally and allow you to be your own best friend as your hormonal functions change.

Hormones are chemicals that are produced by our endocrine glands (like ovaries). They have an intimate relationship with chemicals produced by our brains, called neurotransmitters, such as serotonin, dopamine, and norepinephrine. We’ve all heard the negative expression “raging hormones,” but let’s not lose sight of the fact that our female hormones enhance our physical and mental well-being, help our bodies perform all kinds of elaborate functions, and nourish not only our reproductive organs but our skin, hair, bones, heart, and brain! As women’s health expert Michelle Harrison, M.D., says, “Our hormones don’t make us sick. Our hormones keep us well.”

Our bodies are very sensitive to hormonal effects, and if our hormones are out of balance, the hormonal wellness that Dr. Harrison talks about can be threatened. We may feel as if we’re roller-coastering up and down steep cliffs, or trying to keep our footing on some very rocky ground while wearing three-inch heels.

As we view the hormonal landscape, we’ll pay special attention to four key hormones: estrogen and progesterone, which are produced by the ovaries; and follicle-stimulating hormone (FSH) and luteinizing hormone (LH), both produced by the brain. We tend to think of the path through our hormonal landscape as beginning at menarche (when we had our first period). The first information many of us received about our hormones may have been in that discreet little booklet about menstruation handed out in grade school. It may surprise you, but in fact our journey through the hormonal landscape starts at birth.

Female infants are born with approximately two million potential eggs (follicles) in our ovaries. By the time we reach puberty, usually at age 12 or 13, we have only 400,000 follicles left. No one understands where these follicles go or exactly why eighty percent of them vanish, but they do.

As adult women, we fully understand the value of preparation and planning ahead, organizing dozens of things on a daily basis for our families, jobs, and other commitments. The same advance planning occurs in nature as our bodies prepare to reach our biological milestones. Our hormonal changes over time are neither sudden nor precipitous but gradual.

Like menopause, menarche, the onset of our first period, is not a sudden hormonal event but one outcome of a very deliberate process. Our ovaries were already producing estrogen during our prepubescent years, at ages 9, 10, and 11, to get our bodies ready for the reproductive years ahead.

Sharon was startled when her daughter, a third grader, started to develop breasts. “She’s only nine years old. I can’t believe it! The other day we ended up sharing the bathroom as she was finishing her shower. I noticed the beginning of breasts, and it really took me by surprise. Does this mean she’ll start menstruating soon?” Sharon asked me.

Sharon’s young daughter’s body was definitely showing signs of early hormonal stimulation. But it didn’t necessarily mean that she would start her period any day. Sharon herself had experienced menarche at age 10. Chances are her daughter would follow that pattern fairly closely. In fact, most women’s reproductive history (the timing and pattern of menarche, perimenopause, and menopause) is very similar to their mothers’. Sharon and I also talked about how this would be a wonderful time for her to discuss menstruation with her daughter.
At 48, Sharon’s own body was changing along with her daughter’s, at a different point on the same female developmental arc. As her body gradually wound down its reproductive function, her once-predictable menstrual cycle had become irregular. In fact, her daughter’s changes tuned her in more closely to her own changed relationship with herself as a perimenopausal woman.

“There’s a bittersweet feeling about seeing my daughter start to mature at the same time I’m observing my own body changes,” Sharon said. “The timing seems appropriate, though. It makes sense that I’m about to pass the torch to her, even though I find myself deep in thought as I watch her growing up.”

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Women with a family history of heart disease may find themselves buffeted by conflicting information about hormone replacement therapy and heart protection. I want to emphasize here that when it comes to protecting your heart, HRT needs to be weighed as one of a range of options you have. A family history of heart disease is one factor to consider in evaluating the benefits of HRT, evidence shows that HRT can reduce the incidence of heart disease by as much as 30 to 50 percent. But in our forties the tools at our disposal to strengthen and protect our hearts certainly aren’t limited to medication. I prefer to aim for the overall goal of good health and resilience and do what we can do now, on our own, to achieve it without medical intervention.

Perimenopause is a time to begin anew, to make a strong commitment to taking better care of ourselves than we ever have before. A very important aspect of your self-care is paying attention to what your heart is telling you. It’s true that men and women who report cardiac symptoms are often treated very differently by the health care system, but it’s also true that women themselves often dismiss signals of heart trouble. If you have any concern about a possible cardiac symptom, you owe it to yourself to be sure that this symptom is fully explored. And you may have to be assertive in insisting that it be checked out, if your health care provider seems reluctant to do so or if he or she wants to attribute it to anxiety without any futher exploration. In other words, you may have to take the lead in educating your health care provider about the risks of heart disease in women.

The American Heart Association lists these warning signs of a heart attack:

- Uncomfortable pressure, fullness, squeezing, or pain is felt in the center of the chest, lasting more than a few minutes.

- The pain may spread to the shoulders, neck, or arms.

- Chest discomfort with lightheadedness, fainting, sweating, nausea, or shortness of breath may also occur.

If you have pain in your chest radiating into your left arm; tightness in your chest accompanied by shortness of breath; or palpitations, contact your health care provider right away. Note that palpitations can also be a symptom of perimenopause. Some perimenopausal women say their heart pounds abnormally hard or fast when they are having a hot flash, while others have palpitations that are not connected to hot flashes. Again, I want to underscore the importance of not making any assumptions about these symptoms. Talk them over with your health care provider and ask to have the appropriate investigation to rule out a heart problem.

Women who are affected by cardiovascular disease have a less favorable prognosis than men, for a host of reasons. In the past, the medical community tended to interpret danger signs differently for men and women, although this is slowly changing. Still, palpitations in women are frequently attributed to anxiety, while in men they are viewed as a more serious sign of potential heart disease. A more complete diagnostic workup will usually be done on a man who reports chest pain than on a comparable woman. The medical community is beginning to pay closer attention to signs of heart disease in women, a long overdue change mat women in our age group can take credit for because we have insisted upon being heard.

If a woman is incorrectly diagnosed as having anxiety, however, when heart disease is the real culprit, her treatment will be delayed or inappropriate. By the time the problem is correctly identified, she will probably have more advanced coronary disease than her male counterpart. Delaying treatment for coronary disease lessens the opportunity for effective intervention. Again, if you experience the warning signs of a heart attack, there are two rules to heed: get medical help immediately, and insist that a heart attack be ruled out. Honoring and respecting yourself means listening to your body when it is talking to you.

The Female Heart cites sobering statistics on women who have heart attacks:

- Thirty-nine percent of all women heart attack victims will die within the first year of the attack, versus 31 percent of all men.

- A woman is twice as likely as a man to die within the first sixty days of a heart attack.

- After a first heart attack, a woman is twice as likely as a man to have a second heart attack.

These statistics can be alarming; especially for those of us whose mothers or fathers have had heart attacks. But you don’t have to feel like you may suddenly be blindsided by a heart attack, there is a lot you can do to keep your heart healthy so you don’t find yourself facing those post-heart attack odds. For example, smoking not only causes lung cancer and emphysema but also increases the risk of heart attack. You can cut your risk of heart disease by stopping smoking, exercising regularly (women who exercise regularly are three times less likely to have hearts disease than those who don’t), minimizing your stress level, and paying attention to your diet.

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The reasons for female infertility in the forties vary. Women may no longer ovulate on a regular monthly schedule, which lowers our odds of conceiving. Some women conceive but miscarry very early, often before they have even missed their period. Jayne felt sure she was pregnant, although her period was only three days late. She had been trying to have a baby for nearly three years. She looked sorrowful as she described forcing herself to wait three days, then rushing to the drugstore for a home pregnancy test. “I got home and ran into the bathroom, but my period had started,” she said. “I was crushed. I have a feeling I miscarried, because my period was so heavy and I had so much cramping that month. Besides, in all the years I’ve been trying to get pregnant, my period has never been three days late.”

It’s hard to know if Jayne indeed had a very early miscarriage. Some women have a condition called “late luteal phase defect,” when their bodies do not produce enough progesterone during the second half of their menstrual cycle, the luteal phase. Because progesterone is vital in order to implant and sustain a fertilized egg successfully, its absence may be implicated in infertility. This may be particularly true as we age and our production of progesterone and other hormones declines.

I suggested that Jayne consider having her hormones measured to determine if low progesterone could be a variable in her inability to conceive. If her progesterone level was low, I explained that natural progesterone supplementation is benign and noninvasive and can be taken while a woman is trying to conceive. Some infertility specialists use progesterone supplementation during the first trimester of pregnancy to help sustain a fetus once a woman is pregnant. It turned out that Jayne’s progesterone level was fine. She still wanted to conceive and intended to continue with her fertility specialist.

The older we get, the less viable for fertilization the eggs produced by our bodies may be. In some cases, no direct cause for the inability to conceive can be found. A woman in her forties who is dealing with infertility may decide that reproductive technology is appropriate and affordable. Others who try these highly sophisticated and very expensive methods to conceive may have to stop, either because they can’t afford any more treatments or a certain number of attempts have failed. Gabrielle reached that point after her second attempt at in-vitro fertilization using donor eggs was unsuccessful. She was 42, and the fertility specialist she and her husband were working with said there was no clinical reason not to try a third time if they wanted to. But after many tears, she and her husband decided not to go through the cycle again, which taxed them physically, emotionally, and financially.

“We could have kept going, because there’s always the hope that conception and full-term pregnancy will happen next time,” said Gabrielle. “But we had to look at what it would do to both of us if we had another unsuccessful attempt. Also, the third attempt would have depleted our financial reserves completely. I’m glad we went as far as we did to have a biological child,” she continued, “because at first I wasn’t going to have any treatment. I didn’t think I could take the stress. But I found strength I didn’t know I had.”

The escalations of hope followed by the sharp descents into disappointment had placed a great strain on her marriage, Gabrielle said. “I thought I was going to end up without a husband too. We’ve weathered the shakiest times. We’ve come through the experience of infertility with the realization that we are committed to this marriage, with or without children.”

For some women who want to build a family, adoption is a viable option, but if they are married to men who prefer to remain childless rather than adopt, these differing goals are not simple to resolve. Beth said, “I know my husband and I could be loving parents. I think our purpose in that role is larger than replicating our DNA, but my husband feels strongly about having biological children. We went through a period where neither of us was listening to the other about this issue. I thought he was being completely egotistical and selfish, and he saw my feelings as a highly romanticized view of what it would really be like to adopt a child.”

Beth is 41 and her husband is 44. Finally they sought help from a counselor, who guided them to a point where they were going to explore adoption step by step, making a decision at each point. “This approach really works for me,” Beth said. “We’re not saying we’re going to go full steam ahead and adopt, but we’re not ruling it out either. We’ve both agreed that our overarching goal is to be a loving family, whether that’s two of us or eventually more. With that goal in mind, we can evaluate all of our options. If any part of the adoption process feels like too much of a threat to our family stability, we’ll reassess.”

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Some women who decide to address their perimenopausal health with a herbal or homeopathic approach have the option of working with a naturopathic or homeopathic health care provider or an herbalist. Others have less flexibility, there may not be an expert in these areas near where they live, or the panel of providers from which their insurance coverage permits them to choose may not include an individual who has this expertise. I do encounter lots of women who have a good relationship with their current health care provider, although they are uncertain if he or she will be receptive to trying complementary approaches.

To women who are interested in beginning a dialogue with their health care provider about complementary approaches, I usually recommend these talking points:

- Begin by talking about your overall treatment goals:
Tm most interested in managing hot flashes and headaches.” “Fatigue is a primary concern for me; I’d like to see what I can do to have the energy I need to move through my days.” “Anxiety has started to interfere with my work or family life, and I would like to talk about ways to feel calmer and more in control.” “I’ve had several bladder infections within the last few months. I would like to get them under control.”

- If your health care provider is not familiar with complementary approaches, it’s best to give him or her a clear idea about what you are thinking of trying and why. You’ll need to have done your homework. In other words, be specific: say “I would like to try St. John’s wort to help with my depression for a month” rather than “I was thinking of trying herbs.”

- Give a clear reason for wanting to try the complementary approach. You don’t have to defend or justify your position, but try to articulate the reasoning behind your interest in a particular remedy: “I am more comfortable trying a no drug remedy to begin with, to see if it helps, before trying a prescription.” “I’m not yet ready to begin hormone replacement therapy. I need additional time to evaluate my options, and in the meantime I’m interested in trying black cohosh to see if it will relieve my insomnia.”

- Be prepared to offer backup information or documentation. Journal articles are best, the majority of health care providers would not have time to look through an entire book, and many are unaccustomed to relying on articles in the lay press for information they can use in their practices. You can ask your health care provider if he or she is interested in seeing an article about the particular approach you want to try.

Suppose you’ve done all these things, but your provider is still resistant, and switching to another provider isn’t an option for you now. One of my patients used her strong negotiating skills with her provider. “You would think I’d mentioned snake oil the first time I told him I wanted to see if ginkgo would be useful in counteracting the bouts of forgetfulness I’d been having,” said Lila, a 47-year-old who negotiates labor contracts for a major utility company. “He rolled his eyes heavenward and basically said something like, ‘It’s okay, but you’re on your own.’ I just came out and asked him what we needed to do to reach an agreement, because I respected him and wanted to continue with him but I also wanted to feel that I had the latitude to make some decisions too. He seemed very surprised when I said that. I guess he just expected that I would either go away and take ginkgo without mentioning it again, or else I’d do what he was recommending, which was to start HRT sooner rather than later.”

Lila’s provider did agree to make a note in her chart that she was going to try ginkgo: “I had to take the lead and say I’d call him in two months and let him know how it was working, and that I’d come back in in three and look at the whole picture, HRT included, again.”

The next time Lila saw her provider, she brought up the subject of black cohosh. “He listened to me quite carefully,” she recounted to me, “when I talked about the fact that it has been researched in Europe and that millions of prescriptions for it are written there every year. I said I wanted to give it a try, I wasn’t sure if ginkgo was doing the trick for me because I still had times when my mind seemed to be working slowly and I had also noticed more moodiness. He ended up reading the article I gave him, and he did prescribe it for me. I didn’t feel like I had browbeaten him or whined, either. I made a solid case,” Lila concluded with satisfaction.

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First of all, hormone replacement therapy is a term that confuses many of us. “Hormone replacement therapy? Does that mean estrogen?” is a question I still hear. The answer is yes and no. Yes, HRT includes estrogen. No, not estrogen alone, unless your uterus has been removed by a hysterectomy. Even if your uterus has been removed, you and your health care provider may decide that estrogen and other hormones are necessary.

A typical HRT regimen includes:

- a type of estrogen

- a type of progesterone, either natural progesterone or one of the synthetic progestins

- if needed, an androgen such as testosterone

History accounts for some of the confusion between “hormone replacement” and what was once called “estrogen replacement.” In the 1960s and early 1970s, estrogen was prescribed by itself to women who had perimenopausal symptoms. In fact, just about every woman who complained of a hot flash was put on estrogen replacement therapy. Estrogen taken alone, without natural progesterone or a synthetic progestin, is called unopposed estrogen replacement therapy.

Prescribing unopposed estrogen replacement therapy became a routine practice, until an alarming trend started to emerge in the early 1970s: more women taking estrogen were developing uterine abnormalities. Something clearly was wrong.

Estrogen was identified as the culprit, and it was discovered that estrogen alone can stimulate the growth of irregular or even precancerous cells in the uterus. Without progesterone, estrogen causes the uterine lining (endometrium) to build up instead of sloughing regularly. The cells become increasingly crowded and may become misshapen or malformed. Cell changes could result that are potentially dangerous, possibly leading to cancerous conditions.

The discovery of the link between estrogen-only regimens and increased risk of uterine cancer set off widespread alarm. In an abrupt reversal of the promise that estrogen would keep them forever young, women were taken off estrogen en masse. In my view, this was regrettable for three reasons. First, many women really benefited from estrogen. Second, in many cases estrogen therapy was stopped before medical professionals understood that the missing piece of the puzzle was progesterone. Third, anxiety and confusing information about HRT and cancer persist today, even though we now know that a combination of estrogen and progesterone mirrors the body’s natural balance and avoids estrogen-only promotion of irregular uterine cell growth.

Today HRT is different from the estrogen-only approach of the 1960s and early 1970s. For one thing, estrogen dosages, both in HRT regimens and in oral contraceptives, are significantly lower. For another, estrogen is now combined with natural progesterone (or a synthetic progestin) for women who still have their uterus intact. While the estrogen causes the uterine lining to thicken, the progesterone ensures that the lining is regularly sloughed in the form of a menstrual flow.

(A note here for women who have had a hysterectomy and therefore does not have a uterus. Estrogen alone poses no risk of uterine cancer after hysterectomy because there is no uterine lining to be over stimulated. However, some women who have had hysterectomies still choose to take estrogen with natural progesterone because natural progesterone has bone-building properties and can also have a calming effect on mood.)

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Among the hundreds of beneficial effects that estrogen has in the body, this key hormone protects the heart by keeping the lining of the veins and arteries slippery and free of plaque buildup, so that blood can move freely through them. Plaque (like the plaque that builds up on teeth if we don’t brush them) takes the form of granular, sand like particles, and in our blood these particles can attach themselves to the sides of veins and arteries if those surfaces are rough.

Plaque-filled artery and vein walls are something like a plugged-up garden hose. If you ran chocolate syrup through your garden hose every day, the syrup would eventually stick to the sides and harden. After a while the opening in the hose would be too small to let anything through. In the bloodstream estrogen prevents plaque from getting a stronghold and sticking to vein and artery walls, which then could result in narrower openings that restrict blood flow.

Estrogen also impacts on cholesterol. We’ve heard the word cholesterol for years now, but what exactly is it? It’s a waxy, fatlike substance found in the blood. Not all cholesterol is the same, as you may know. “Good” cholesterol is called HDL, and it’s considered good because it transports cholesterol and other lipids (fatlike substances) from the body. The “bad” cholesterol is called LDL, and it has a negative impact because it delivers lipids to body tissues.

The ratio between HDL and LDL is extremely important. We want to have a high level of HDL in relation to LDL. A good HDL-to-LDL ratio is 3 to 1, according to Dr. Legato’s book, the female Heart. Estrogen helps keep the HDL high and the LDL low.

Your weight, family history, and ethnicity have some bearing on the health of your heart. For example, if your father had a heart attack before age 56 or your mother had a heart attack before age 60, your risk of heart disease increases. Carrying around extra pounds also places you in a higher risk category, particularly if your weight is 20 to 30 percent higher than the acceptable range for your height. If you have a history of heart disease in your family, you have more reason to be concerned about your heart than a friend who doesn’t have the same kind of family history.

Mary lost her father to heart disease fifteen years earlier, when he was only 55. A successful businesswoman, she attributes many of her achievements to the work ethic her father demonstrated and to the guidance he gave her when she was first starting out in the work world. Yet when perimenopausal mood changes and loss of libido started to interfere with her life at 42, she hadn’t stopped to consider that heart disease could potentially be another part of her father’s legacy, it simply hadn’t occurred to her.

Mary is certainly not in any immediate danger, her cholesterol, blood pressure, and triglyceride levels are all within normal ranges. But I felt it was essential that Mary take a proactive approach to minimize the possibility of an unwelcome inheritance of heart disease. I reassured her that history wouldn’t necessarily repeat itself, but I also reminded her that her choices today about what she ate, how she took care of her body’s fitness, and how much stress was a driving force in her life would have a lot to do with her health outcomes in the years ahead.

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One of the kindest things you can do for your body is, quite simply, to move it around. Here I’ll mention some basics about types of movement that provide multiple benefits: less stress, cardiovascular conditioning, more bone strength, and lowered risk of breast cancer.

Yoga is an ideal exercise for forties women for a host of reasons: it tones up our muscles and calms us down. We can do it when and where we like, and we don’t have to buy any equipment, shoes, or outfits. Another beautiful aspect of yoga is that it is a gentle way to begin moving if you’re unaccustomed to exercise. More advanced yoga exercises and poses are suitable for women who regularly exercise. Alternating a more rigorous and jarring form of exercise like running with the soothing and calming stretches involved in yoga is an excellent way to bring balance to an exercise routine. Some yoga poses are weight-bearing, that’s the type of exercise you need to do regularly in order to build bone strength. (Weight-bearing exercise simply means that the weight of your body is supported by your bones.)

Walking is another integrated form of exercise that builds your bones, gets your heart pumping, and can also give you a stress-free break from your hectic pace. The act of walking around, either alone or with someone whose company you enjoy is a conscious way to break away from the pattern of rushing around. You might be surprised at what you notice, as Mary was. The executive who was an avowed no exerciser, Mary had agreed to hand off some of her phone calls late in the day to her assistant so she could take a short walk. “I was very uncomfortable at first,” she said. “I’m just not used to having nothing in my hands. I’m always holding the phone, or the steering wheel of my car, or my briefcase, or the reports I’m reviewing, or I’m pounding the keyboard on my computer. It felt strangely nerve-racking at first to be walking around empty-handed. I felt like I was wasting time.”

To her credit, Mary didn’t give up walking twice a week. “I didn’t want to carry hand weights, so I bought a set of stress balls’ that fit in the palm of your hand. They’re made of soft material that you squeeze. Depending on what my day has been like, I either press them gently or try to pulverize them.” A normally serious person, Mary suddenly laughed.

In our forties, exercise doesn’t have to be about doing bouncing routines to thumping music in a communal room. Some women are combining their exercise routines with an expression of their spirituality, borrowing from ancient traditions where women gave thanks together for water, sun, good crops, and other gifts from the earth. Today a group of women I know who are members of a synagogue regularly gather outside to exercise and pray together. Reaching for the sky, one participant described the gathering as a “way to send prayers directly up to God.” She added, “Exercising and praying at the same time reminds me to be thankful for my body, that it’s healthy and strong.” Ecclesiastical dance brings movement into some masses or church services, using the body to offer praise and thanks for mysteries and miracles that are, perhaps, beyond words.

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Progesterone also seems to have a significant bearing on our moods, producing a calming effect. During pregnancy, progesterone levels soar, reaching levels thirty to fifty times greater than in no pregnant women. That may be why some women say they feel “very serene” during pregnancy, or that they have “never felt better.”

Lynn’s comments on her experience during pregnancy may reflect some of progesterone’s effects: “I couldn’t believe anyone would ever complain about being pregnant. After the first trimester was over, I felt wonderful. My skin and nails looked so healthy, and my attitude about life was great. As far as I was concerned, everything was right with the world.”

Eleven years later, when perimenopausal symptoms of nervousness and irritability started to cast shadows on her normally cheerful outlook, she wished she could have “just one day” of the well-being she felt during her last pregnancy. “I toyed with the idea of having another baby for a lot of reasons, not the least of which was wishing I could feel that good again,” she told me. Lynn’s husband, less nostalgic about the glow of pregnancy and reluctant to readjust his life to care for a newborn again, reacted to her suggestion with shock that was only partially feigned. “His response was ‘Not with me, thank you very much,”‘ Lynn said.

I assured Lynn that pregnancy wasn’t her only option for recapturing the well-being she was missing at 43. “Some women find that supplementing with natural micronized progesterone really eases premenstrual anxiety,” I told her.

When progesterone levels go out of balance during the second half of the menstrual cycle, some women feel their spirits drop premenstrual. This weepy feeling may result from the fact that progesterone levels haven’t risen sufficiently or drop off abruptly during the luteal phase. Another time when progesterone levels fall dramatically is within hours after a woman gives birth. This abrupt hormonal change produces only mild symptoms of depression in some women, while other women feel more acutely depressed after childbirth. In extremely rare cases, women develop postpartum psychosis.

I have found that micronized natural progesterone can be very effective in treating postpartum depression, as well as premenstrual or perimenopausal anxiety. (Micronized means “broken down into very tiny particles.”) There may be a connection between heightened anxiety or even panic attacks and low levels of progesterone. Mary, who had to will herself to “calm down” during the day, may have been feeling the effects of low progesterone.

In the brain, progesterone binds to certain sites where the “antianxiety” brain chemical, GABA, is produced. Progesterone’s effect on the brain is similar to the effect of anti-anxiety medications such as Xanax or Valium, which bind to the same sites. In my clinical and personal experience, I have found that progesterone can be a very effective, noninvasive option for managing symptoms of anxiety. This natural and benign medication (micronized natural progesterone is derived from an extract of yams and soybeans) represents an alternative to other potentially addictive anti-anxiety drugs.

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Hormone replacement therapy often relieves vaginal dryness. But if the combination of hormones in the regimen isn’t suitable for an individual woman, vaginal dryness, burning, uncomfortable intercourse, or stress incontinence persist.

HRT regimens frequently include estradiol and estrone, two types of estrogen. A third type of estrogen, estriol, can often relieve vaginal dryness where other types have failed. Frequently called the “weak” or “forgotten” estrogen, estriol has a good track record in relieving genitourinary symptoms such as vaginal dryness and stress incontinence. Estriol is good for hot flashes too.

Although estriol is commonly used in Europe, it isn’t made in mass quantities in the United States. Many health care providers are unfamiliar with this natural form of estrogen. Each estriol prescription is compounded individually by a pharmacist as an oral capsule, vaginal cream, vaginal suppository, or topical skin cream or gel. Estriol suppositories are dry and need to be moistened before inserting, they aren’t waxy or messy like some vaginal suppositories. Some women prefer to use an estriol skin cream or gel, which is also a prescription medication that must be compounded by a pharmacist.

Dana, a reserved woman with a careful way of speaking, came to see me with this report: “My friends complain about hot flashes, moodiness, and memory lapses. I have none of those problems. What I notice is that lovemaking has become painful, and my friends aren’t talking about that.” She paused for a moment. “Well, I suppose I wouldn’t talk about it even if someone did bring it up.”

“These are deeply personal issues,” I said to Dana. “Many women are uncomfortable talking about their private lives, and besides, it hasn’t exactly been common knowledge that these changes can happen in our forties.”

As we talked more, Dana said that the vaginal discomfort and dryness didn’t happen only during lovemaking. She thought it had started at least a year ago; she is now 47. We talked about her options to manage this symptom, vitamin E or another over-the-counter lubricant and estriol.

After Dana and I discussed her family history and her questions and concerns about HRT, she consulted with her health care provider. Given her symptoms and her overall health profile, neither she nor her healthcare provider thought HRT was necessary for her now. She did, however, decide to try estriol cream, smoothing a very small amount (0.05 mg) on her hands twice a day for thirty consecutive days. She was also going to use vitamin E oil, which can be applied directly to the vagina. As we have discussed, estriol does not affect breast or uterine tissue. Unlike other estrogens, it can be taken without natural progesterone or synthetic progestin, because it does not stimulate the uterine lining. Dana had good results with estriol cream and vitamin E. When I saw her last and asked how she was doing, she said, “There has been a complete turnaround.” I took that to be her circumspect way of saying that her vaginal symptoms had improved and, I hope, that she was much more able to enjoy lovemaking again.

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